A Marfan syndrome gene expression phenotype in cultured skin fibroblasts
Abstract Background Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the fibrillin-1 gene.This syndrome constitutes a significant identifiable subtype of aortic aneurysmal disease, accounting for over 5% of ascending and thoracic aortic aneurysms.Results We used spotted membrane DNA macroarrays to identify gene